Fluorine-19 Mri Contrast Agents for Cell Tracking and Lung Imaging
نویسندگان
چکیده
منابع مشابه
Fluorine-19 MRI Contrast Agents for Cell Tracking and Lung Imaging
Fluorine-19 ((19)F)-based contrast agents for magnetic resonance imaging stand to revolutionize imaging-based research and clinical trials in several fields of medical intervention. First, their use in characterizing in vivo cell behavior may help bring cellular therapy closer to clinical acceptance. Second, their use in lung imaging provides novel noninvasive interrogation of the ventilated ai...
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BACKGROUND In this study we used cellular magnetic resonance imaging (MRI) to detect mesenchymal stem cells (MSC) labeled with a Fluorine-19 (19F) agent. 19F-MRI offers unambiguous detection and in vivo quantification of labeled cells. METHODS We investigated two common stem cell transplant mouse models: an immune competent, syngeneic transplant model and an immune compromised, xenograft tran...
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PURPOSE Cellular therapeutics are emerging as a treatment option for a host of serious human diseases. To accelerate clinical translation, noninvasive imaging of cell grafts in clinical trials can potentially be used to assess the initial delivery and behavior of cells. METHODS The use of a perfluorocarbon (PFC) tracer agent for clinical fluorine-19 ((19) F) MRI cell detection is described. T...
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ژورنال
عنوان ژورنال: Magnetic Resonance Insights
سال: 2015
ISSN: 1178-623X,1178-623X
DOI: 10.4137/mri.s23559